About our group
Our research is focused on cathepsin proteases and proteolytic systems controlled by these enzymes. They play a critical role in a number of pathologies such as cancer, osteoporosis, neurodegenerative and immune diseases. Cathepsin-like proteases are also essential for viability or virulence of important human pathogens, parasites and pests. In our work, we employ methods of biochemistry, molecular biology and structural biology to reveal mechanisms of function and natural regulation of cathepsins and related proteases. Armed with this knowledge, we develop cathepsin inhibitors as a molecular tool for new therapeutic strategies.